S Ageb Physique mass indexc 25 25?9.9 30 Family history of colorectal cancer in any first-degree relative Common use of aspirin Postmenopausal hormone use (ever) Physical activity, MET-hours/weekd Alcohol consumption, g/day Total calories, kcal/day Red meat intake, servings/day Cumulative pack-years Pack-years smoked prior to age 30b 20 years of ageb at commence of smoking, 70 21 9511,458 68.9 (eight.7) 70 21 9325,952 70.0 (7.9) 74 19 7124,626 68.7 (eight.three) 79 16 5191,635 68.1 (8.0) 69 27 5188,401 61.1 (11.0) 66 29 5156,652 65.1 (10.4) 64 30 636,951 59.8 (ten.4) 71 25 430,770 59.eight (9.eight)40 63 15.8 (17.5) three.8 (7.0) 1,697 (449) 1.1 (0.6) N/A N/A N/A42 68 17.3 (19.four) 7.1 (9.three) 1,672 (430) 1.0 (0.six) 13.1 (13.5) six.eight (six.1)43 63 15.6 (18.6) 7.8 (10.four) 1,638 (439) 1.1 (0.6) 29.six (20.8) 6.three (5.0)42 56 13.5 (17.6) 9.1 (12.4) 1,637 (463) 1.2 (0.7) 40.3 (21.8) 6.7 (four.4)45 N/A 31.3 (29.four) 7.9 (11.1) 1,985 (554) 1.1 (0.eight) N/A N/A N/A49 N/A 30.2 (28.1) 13.1 (14.six) 1,966 (549) 1.1 (0.8) 19.5 (15.six) ten.6 (6.9)49 N/A 25.two (25.2) 14.7 (16.three) 1,970 (571) 1.3 (0.9) 32.0 (22.5) 9.9 (six.7)45 N/ASmoking Cessation and Colorectal Cancer Epigenetics23.0 (24.5) 16.eight (18.8) two,012 (589) 1.5 (0.9) 39.7 (24.six) 10.2 (six.six)Abbreviations: MET, metabolic equivalent activity; N/A, not applicable; SD, typical deviation. a Updated information and facts of smoking status from biennial questionnaires was averaged, utilizing person-years in each category of smoking status as much as censoring (like death from other causes) or straight away before private colorectal cancer diagnosis if it occurred. Values had been standardized for the age distribution from the study population. b Not age-adjusted. c Weight (kg)/height (m)two. d MET calculated as outlined by the frequency of a selection of physical activities in 1986 for each women and men.88 Nishihara et al.Table two. Duration of Smoking Cessation and Incident Colorectal Cancer Risk by Molecular Subtypesa within the Nurses’ Health Study (1980?008) and the Wellness Pros Follow-up Study (1986?008)Current Smoker (n = 439,508 person-years) HR 95 CI Cessation for 1? Years (n = 161,905 person-years) HR 95 CI Cessation for five? Years (n = 155,720 person-years) HR 95 CI Cessation for 10?9 Years (n = 312,757 person-years) HR 95 CI Cessation for 20?9 Years (n = 511,426 person-years) HR 95 CI Cessation for 40 Years (n = 126,688 person-years) HR 95 CIPtrend bPheterogeneity cCancers All colorectal cancer No. Age-adjusted Multivariated Proximal colon cancer No.Buy(2-Cyanopyridin-3-yl)boronic acid Age-adjusted Multivariated Distal colorectal cancer No.2-Chloro-5-hydroxyisonicotinic acid Order Age-adjusted Multivariated CIMP-low/negative No.PMID:25016614 Age-adjusted Multivariate CIMP-high No. Age-adjusted Multivariate MSS No. Age-adjusted Multivariated MSI-high No. Age-adjusted Multivariated 1.00 1.00 27 Referent Referent 1.27 1.29 16 0.68, 2.37 0.69, two.40 0.97 0.96 14 0.51, 1.86 0.50, 1.84 0.66 0.67 20 0.37, 1.19 0.37, 1.20 0.50 0.50 30 0.29, 0.84 0.29, 0.85 0.60 0.62 17 0.31, 1.13 0.33, 1.17 0.001 0.002 Table continues 1.00 1.00 108 Referent Referent 0.83 0.83 40 0.57, 1.19 0.58, 1.20 1.34 1.34 68 0.98, 1.82 0.98, 1.82 0.97 0.97 101 0.74, 1.28 0.73, 1.28 0.93 0.94 201 0.73, 1.19 0.74, 1.20 0.96 0.98 86 0.71, 1.30 0.72, 1.33 0.26 0.36 0.d d139 1.00 1.00 Referent Referent 63 1.00 1.00 Referent Referent 75 1.00 1.00 Referent Referent 0.82 0.83 1.16 1.17 0.98 0.60 0.72, 1.33 0.73, 1.34 32 0.76, 1.78 0.76, 1.80 28 0.53, 1.27 0.54, 1.29 1.26 1.26 1.32 1.32 1.31 1.86 1.00, 1.71 0.99, 1.71 42 0.89, 1.96 0.89, 1.96 43 0.86, 1.84 0.86, 1.84 1.03 1.03 0.86 0.86 0.96 0.129 0.75, 1.22 0.