Persistent luminescence {without|with out|without having|with no|devoid of|without the need of} excitation light and tissue autofluorescence interference holds {great|fantastic|excellent|wonderful|good|terrific} {promise|guarantee} for in vivo imaging and sensing. {However|Nevertheless|Nonetheless|Even so|On the other hand|Having said that}, the availability of persistence luminescence {materials|supplies|components} is largely {limited|restricted} by {potential|possible|prospective} toxicity, instability, short-wavelength emissions, and poor clinical {potential|possible|prospective} for {currently|presently|at present|at the moment} {available|accessible|obtainable|offered|readily available|out there} ones. {Here|Right here} we report a series of porphyrin derivatives with near-infrared (NIR) persistence luminescence for image-guided cancer surgery and drug screening. These porphyrin derivatives showed NIR persistence luminescence {over|more than} 760 nm {after|following|right after|soon after|immediately after|just after} cessation of excitation light or upon interaction with peroxynitrite (ONOO-), {and a|along with a|as well as a|plus a|and also a|in addition to a} plausible mechanism of ordered oxidation of vinylene bond is proposed. {Through|Via|By means of|By way of} molecular engineering with adaptive peptides bearing the functions of β-sheet-formatting and cancer cell targeting, the resultant Ppa-FFGYSA supermolecular probe showed enhanced photoacoustic and persistence luminescence signals, facilitating preoperative photoacoustic tumor identification and intraoperative persistence luminescence image-guided tumor resection with outperformed signal-to-background ratio. {In addition|Additionally|Furthermore|Moreover|Also}, the activated persistence luminescence in recognition of ONOO- also permits the {specific|particular|certain|distinct|precise} monitoring of neutrophil infiltration and screening of immunogenic cell death (ICD) drugs with {high|higher} sensitivity and specificity. Price of 1,7-Dibromoheptane 2223047-95-6 supplier PMID:35901518
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