Herein reported {is a|is really a|is actually a|can be a|is often a|is usually a} {strategy|technique|method|approach|tactic} for constructing vicinal 4°/3° carbons {via|by way of|through|by means of} reductive Cope rearrangement. Substrates {have been|happen to be|have already been} {designed|developed|created|made} which exhibit Cope rearrangement kinetic barriers {in the|within the|inside the} {range|variety} of ~23 kcal/mol with isothermic favorability (DG ~0). These fluxional/shape-shifting molecules {can be|may be|could be|might be|is often|is usually} driven forward by chemoselective reduction to {useful|helpful|beneficial|valuable} polyfunctionalized {building|developing|creating|constructing} blocks. Price of 83249-08-5 2-Methyl-1H-indole-7-carboxylic acid Data Sheet PMID:23776646
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