ABSTRACT: Intermolecular hydroamidation of internal alkynes has been a long-standing challenge, {one of the most|probably the most|just about the most} {successful|effective|productive|profitable|prosperous|thriving} examples so far is silver-catalyzed hydroamidation of siloxy-alkynes for which meet the {standards|requirements} of atom {economic|financial} and mild reaction {conditions|circumstances|situations} of {ideal|perfect|best|excellent} hydroamidation. {However|Nevertheless|Nonetheless|Even so|On the other hand|Having said that}, the mechanism of this reaction remains controversy. {Using|Utilizing|Making use of|Employing|Working with|Applying} density function theory (DFT), we revealed that the reaction {takes|requires} {place|location|spot} {through|via|by means of|by way of} a silylium ion migration mediated hydroamidation (SMH) pathway. The SMH pathway goes {through|via|by means of|by way of} two {steps|actions|measures|methods}, {the first|the very first|the initial} step is Ag+ promoted proton and silylium ion exchange {between|in between|among|amongst|involving} siloxy-alkynes and amide, {leading|top|major} to ketene and silyl-imines, the second step is Ag+ catalyzed nucleophilic addition {between|in between|among|amongst|involving} ketene and silyl-imines, following {with a|having a|using a} silylium ion migration afford the final {product|item|solution}. {In this|Within this} reaction, Ag+ activate the siloxy-alkyne into silylium ion and silver-ketene {through|via|by means of|by way of} p-π conjugate {effect|impact}, the silylium ion then act as catalyst. {According to|Based on|In accordance with|In line with|As outlined by} our calculation, the scopes of alkynes {in this|within this} reaction {may|might|could|may possibly|may well|may perhaps} be extend to silyl-substituted ynamines or silyl-substituted ynamides, {and the|and also the|as well as the|along with the|plus the} scopes of amide {maybe|perhaps|possibly} expanded into p-π conjugate {system|method|program|technique} {such as|like|including|for example|for instance|which include} diazoles, diazepines and so on. Our calculations also reveal a concise {way to|method to|approach to|strategy to|technique to|solution to} construct substituted enamides {through|via|by means of|by way of} Ag+ catalyzed nucleophilic addition {between|in between|among|amongst|involving} ketenes (or ketene imines) and silyl-substituted p-π conjugate {system|method|program|technique} {such as|like|including|for example|for instance|which include} silyl-imines, silyl-diazoles. Geranylgeraniol Order 1,18-Dibromooctadecane manufacturer PMID:24883330
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