{The use of|The usage of} {small|little|tiny|modest|smaller|compact} molecules to induce targeted protein degradation is increasingly {growing|expanding|developing|increasing} {in the|within the|inside the} drug discovery landscape and protein degraders have progressed {rapidly|quickly|swiftly} {through|via|by means of|by way of} the pipelines. {Despite|Regardless of|In spite of} the advances {made|produced|created} so far, their synthesis {still|nonetheless|nevertheless} represents a {significant|substantial|considerable|important} burden and new approaches are urgently demanded. Herein, we report an unprecedented platform that leverages the modular nature of {both|each} multicomponent reactions and degraders to {enable|allow} the preparation of {highly|extremely|very|hugely} decorated PROTACs and hydrophobic tag-mediated degraders. {Compared to|In comparison to|In comparison with|When compared with} the {existing|current} {methods|techniques|strategies|approaches|procedures|solutions}, our {approach|method|strategy} {offers|provides|gives|delivers|presents} a versatile and cost-effective {means|indicates|implies|signifies|suggests} to access libraries of protein degraders and {increase|improve|boost|enhance|raise} the {chance|opportunity|likelihood|possibility} of identifying {successful|effective|productive|profitable|prosperous|thriving} clinical candidates. 878155-85-2 web 1261451-92-6 In stock PMID:23937941
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