A {general|common|basic} {approach|method|strategy} for the synthesis of bis(imidazolium) dichloride salts from imidazoles and dichloroalkanes is reported. {Typical|Common|Standard} limitations of this reaction for the formation of methylene-bridged derivatives are addressed herein {through|via|by means of|by way of} {the use of|the usage of} an excess CH2Cl2 {in the|within the|inside the} presence of DMSO as a polar cosolvent, {significantly|considerably|substantially|drastically} {improving|enhancing} conversion {rates|prices} presumably {via|by way of|through|by means of} stabilization {of the|from the|in the|on the|with the|of your} initial SN2 transition state. The {method|technique|approach|strategy|system|process} was also shown {to be|to become} applicable {to the|towards the|for the} formation of bis(pyridinium) dichloride salts from pyridine derivatives, and {to the|towards the|for the} direct synthesis of metal-bis(NHC) complexes from imidazoles. 3-(Trifluoromethyl)pyrazole Data Sheet 4-Bromobenzoic acid custom synthesis PMID:23008002
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