Cyanopyridylalanines are non-canonical amino acids that react with aminothiol compounds {under|below|beneath} physiological {conditions|circumstances|situations} {in a|inside a|within a} biocompatible manner {without|with out|without having|with no|devoid of|without the need of} requiring added catalyst. {Here|Right here} we present newly {developed|created} aminoacyl-tRNA synthetases for genetic encoding of meta- and para-cyanopyridylalanine to {enable|allow} the site-specific attachment of a wide {range of|selection of|array of} {different|various|distinct|diverse|unique|distinctive} functionalities. The outstanding utility {of the|from the|in the|on the|with the|of your} cyanopyridine moiety is demonstrated by examples of (i) post-translational functionalization of proteins, (ii) in-cell macrocyclization of peptides and proteins, and (iii) protein stapling. The biocompatible nature {of the|from the|in the|on the|with the|of your} protein ligation chemistry enabled by the cyanopyridylalanine amino acid opens {a new|a brand new} path to {specific|particular|certain|distinct|precise} in vivo protein modifications in {complex|complicated} biological environments. N-Boc-O-tosyl hydroxylamine Data Sheet DSG Crosslinker custom synthesis PMID:23812309
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