Synthesis {of the|from the|in the|on the|with the|of your} C19-truncated maltepolide E has been {accomplished|achieved} {via|by way of|through|by means of} a diene–ene RCM {strategy|technique|method|approach|tactic} {without|with out|without having|with no|devoid of|without the need of} {damage|harm} {to the|towards the|for the} C11–C14 alkenyl epoxy unit. Upon release {of the|from the|in the|on the|with the|of your} C17-OH group, it attacked {at the|in the} C14 position with double bond migration and epoxide ring-opening to furnish the C19-truncated maltepolide A and B as proposed for the biosynthesis of maltepolides. Preliminary cytotoxicity {data|information} {of the|from the|in the|on the|with the|of your} synthesized C19-truncated maltepolides against L929 mouse fibroblast cell line {suggest|recommend} irrelevance {of the|from the|in the|on the|with the|of your} vinyl epoxide and {importance|significance|value} {of the|from the|in the|on the|with the|of your} conjugated dienyl keto unit for the observed anticancer activity. 5-Azidopentan-1-amine supplier 2248702-12-5 web PMID:33679749
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