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Iranian Journal of Pharmaceutical Analysis (2013), 12 (4): 611-621 Received: July 2012 Accepted: AprilCopyright ?2013 by College of Pharmacy Shaheed Beheshti University of Medical Sciences and Wellness ServicesOriginal ArticlePreparation of Cefquinome Sulfate Proliposome and its Pharmacokinetics in RabbitQiang FU, Hua-Lin FU*, LUO Huan, Wei ZHANG, Guang SHU, Meng-Jiao LIU, Feng-Ying DENG and Jun HUDepartment of Pharmacy, College of Veterinary Medicine, Sichuan Agriculture University, Ya, an, Sichuan, 625014,China. Abstract Cefquinome Sulfate (CS) is usually a fourth-generation cephalosporin, which has been developed solely for veterinary use. It shows potent antibacterial activity against a broad spectrum of bacterial species. Nonetheless, Cefquinome is susceptible to hydrolysis, which limiting its clinical employment efficacies to some extent. So, in this study, to improve Cefquinome Sulfate biological half-life, a novel Cefquinome Sulfate proliposome was prepared by strong dispersion and effervescent approaches and characterized for morphology, particle size, entrapment efficiency and in vitro release. A Reversed Phase-High Overall performance Liquid Chromatography (RP PLC) process was 1st selected and established to identify the drug concentration in plasma soon after intra muscular (IM) administrating Cefquinome Sulfate remedy and liposome at a single dosage of 18 mg/kg in rabbit. Then their pharmacokinetics in vivo was compared. Final results showed that the received liposome was milky white suspension, spherical or ellipsoidal in shape. The mean particle size was 203? nm and the entrapment efficiency was 53.five?.16 . The cefaquinom sulfate answer a.