{Contemporary|Modern} immunoassays {commonly|generally|typically|frequently|normally|usually} {used|utilized|employed|utilised|applied|made use of} in clinical diagnostics {mostly|mainly|largely} {utilize|make use of|use} enzymes, {such as|like|including|for example|for instance|which include} horseradish peroxidase, for signal generation. {Numerous|Many|Several|Quite a few|A lot of|Various} {research|study|analysis|investigation} is {dedicated|devoted|committed} {to the|towards the|for the} {development|improvement} of artificial peroxidase-mimicking catalysts with {lower|reduce|reduced|decrease} {cost|price|expense}, {high|higher} activity, {better|much better|far better|greater|superior|improved} operational stability, and tunable properties. Herein we synthesized hemin-loaded bovine serum albumin (BSA) nanoparticles and applied them as catalytic labels (nanozymes) in colorimetric immunoassay of anti-tetanus antibodies. Hemin {is a|is really a|is actually a|can be a|is often a|is usually a} {key|important|crucial|essential} {part of|a part of} the peroxidase catalytic center, possessing peroxidase like-activity. Albumin nanoparticles {were|had been|have been} loaded with {multiple|numerous|several|a number of|many|various} hemin molecules and decorated with Streptococcal protein G. Resulting nanozymes possessed {good|great|excellent|very good|fantastic|superior} colloidal stability and {allowed|permitted} for antibody detection in blood serum. The sensitivity of antibody detection was {sufficient|adequate|enough} for the assessment of post-vaccination immunity. 1319716-42-1 web 731810-57-4 web PMID:35345980
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