AKT1 is emerging as a {useful|helpful|beneficial|valuable} target for treating cancer. Herein, we {discovered|found} {a new|a brand new} set of ligands that inhibit the AKT1, as shown by in vitro binding and cell line {studies|research}, {using|utilizing|making use of|employing|working with|applying} a newly {designed|developed|created|made} virtual screening protocol that combines structure-based pharmacophore and docking screens. Taking {together|with each other|collectively} {with the|using the|with all the|together with the} biological {data|information}, the {combination|mixture} of structure {based|primarily based} pharamcophore and docking {methods|techniques|strategies|approaches|procedures|solutions} demonstrated {reasonable|affordable} {success|achievement|good results|accomplishment|results} {rate|price} in identifying new inhibitors (60-70%) proving the {success|achievement|good results|accomplishment|results} of aforementioned {approach|method|strategy}. A detail {analysis|evaluation} {of the|from the|in the|on the|with the|of your} ligand-protein interactions was performed explaining observed activities. 439579-12-1 custom synthesis 2222867-16-3 manufacturer PMID:23577779
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