The biosynthetic gene cluster of fungal bioactive sesterterpenoids, variecolin (1) and variecolactone ({2|two}), was identified in Aspergillus aculeatus ATCC 16872. Heterologous production of 1 and {2|two} was {achieved|accomplished} in Aspergillus oryzae by expressing the sesterterpene synthase VrcA {and the|and also the|as well as the|along with the|plus the} cytochrome P450 VrcB. Intriguingly, the replacement of VrcB with homologous P450s from other fungal terpenoid pathways yielded {three|3} new variecolin analogues, {one|1|a single|one particular} of which exhibited potent anticancer activity comparable to that of 1. tBuBrettPhos Pd G3 Chemscene 1257856-15-7 Purity PMID:23664186
Headquartered in New Jersey, USA, ChemScence is a global leading manufacturer and supplier of building blocks and fine research chemicals. We now have branches in Sweden and India. Our mission is to pave the way for drug discovery by providing the most innovative chemicals with the highest-level quality for a reasonable price.
Our Catalog Products
We deliver an extensive portfolio of products, including Building Blocks,Catalysts&Ligands,Synthetic Reagents,Material Science and ADC Linkers&Protac,.ChemScene now have over 600000 Building Blocks & Intermediates in our catalog and more than 70000 of them are in stock.
For details, please refer to the ChemScene website:https://www.chemscene.com