{We have|We’ve|We’ve got} {discovered|found} a ring-opening fluorination of bicyclic azaarenes. Upon {treatment|therapy|remedy} of bicyclic azaarenes {such as|like|including|for example|for instance|which include} pyrazolopyridines with electrophilic fluorinating agents, fluorination {of the|from the|in the|on the|with the|of your} aromatic ring is followed by a ring-opening reaction. {Although|Even though|Though|Despite the fact that|While} this {overall|general|all round} trans-formation {can be|may be|could be|might be|is often|is usually} classified as an electrophilic fluorination of an aromatic ring, {it is|it’s|it really is|it truly is|it can be|it is actually} a novel {type of|kind of|sort of|form of|style of|variety of} fluorination that {results|outcomes|final results|benefits} in {construction|building} of tertiary carbon–fluorine bonds. The present protocol {can be|may be|could be|might be|is often|is usually} applied to a {range|variety} of bicyclic azaarenes, tolerating azines {and a|along with a|as well as a|plus a|and also a|in addition to a} {variety of|number of|selection of} functional groups. {Additionally|In addition|Furthermore|Moreover|Also|On top of that}, mechanistic {studies|research} and enantioselective fluorination {have been|happen to be|have already been} examined. Methyl 2,3-dihydroxypropanoate Chemscene 1329035-82-6 site PMID:23291014
Headquartered in New Jersey, USA, ChemScence is a global leading manufacturer and supplier of building blocks and fine research chemicals. We now have branches in Sweden and India. Our mission is to pave the way for drug discovery by providing the most innovative chemicals with the highest-level quality for a reasonable price.
Our Catalog Products
We deliver an extensive portfolio of products, including Building Blocks,Catalysts&Ligands,Synthetic Reagents,Material Science and ADC Linkers&Protac,.ChemScene now have over 600000 Building Blocks & Intermediates in our catalog and more than 70000 of them are in stock.
For details, please refer to the ChemScene website:https://www.chemscene.com