The {increased|elevated|improved|enhanced} synthetic utility of organosilanes motivates researchers to {develop|create} a milder {and more|and much more} {practical|sensible} synthetic {methods|techniques|strategies|approaches|procedures|solutions}. Silylzinc reagents, {which are|that are} {typically|usually|normally|generally|commonly|ordinarily} {the most|probably the most|essentially the most|one of the most|by far the most} functional group tolerant, are notoriously {difficult to|hard to|tough to} synthesize {because they|since they|simply because they} are obtained by a pyrophoric reaction of silyllithium, {particularly|especially|specifically} Me3 SiLi itself {prepared|ready} by the reaction of MeLi and disilane. {Furthermore|Moreover|In addition|Additionally}, the dissolved LiCl in silylzinc {may|might|could|may possibly|may well|may perhaps} {have a|possess a} detrimental {effect|impact}. A synthetic {method|technique|approach|strategy|system|process} {that can|that may|that will|that could|which will|which can} {avoid|steer clear of|stay away from|keep away from|prevent|stay clear of} silyllithium and {involves|entails|requires|includes} a direct synthesis of silylzinc reagents from silyl halides is arguably the simplest and economical {strategy|technique|method|approach|tactic}. We describe for {the first|the very first|the initial} time, the direct synthesis of PhMe2 SiZnI and Me3 SiZnI reagents by employing a coordinating TMEDA ligand, {as well|also|too|at the same time} as single crystal XRD structures. Importantly, {they can|they are able to|they’re able to|they could|they will} be obtained as {solid|strong} and stored for longer periods of time. We demonstrate their significance in cross-coupling of {various|numerous|different|a variety of|several|many} {free|totally free|free of charge|cost-free|absolutely free|no cost} alkyl/aryl/alkenyl carboxylic acids with broader functional group tolerance and API derivatives. The {general|common|basic} applicability and efficiency of {solid|strong} Me3 SiZnI are shown {in a|inside a|within a} wide {variety|selection|assortment|range|wide variety} of reactions {including|such as|which includes|like} alkylation, arylation, allylation, 1,4-addition, acylation {and more|and much more}. Spiro[2.5]octane-1-carboxylic acid Order 1314538-55-0 Formula PMID:23577779
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