Two dimensional covalent organic frameworks(2D-COFs) are a class of crystalline porous organic polymers that consist of covalently linked, two dimensional sheets {that can|that may|that will|that could|which will|which can} stack {together|with each other|collectively} {through|via|by means of|by way of} non-covalent interactions. {Here|Right here} we report the synthesis of a novel COF, {called|known as|referred to as|named} PyCOFamide, which has an experimentally observed pore size {that is|that’s|which is|that is certainly|that is definitely|that may be} {greater|higher} than {6|six} nm in diameter. {This is|This really is|This can be|That is} {among|amongst} the {largest|biggest} pore size reported to date {for a|to get a|for any} 2D-COF. PyCOFamide exhibits permanent porosity and {high|higher} crystallinity as evidenced by the nitrogen adsorption, powder X-ray diffraction, and high-resolution transmission electron microscopy. We show that the pore size of PyCOFamide is {large|big|huge|massive|substantial|significant} {enough|sufficient|adequate} to accommodate fluorescent proteins {such as|like|including|for example|for instance|which include} Superfolder green fluorescent protein and mNeonGreen. This {work|function|perform|operate} demonstrates the utility of non-covalent structural reinforcement in 2D-COFs to {produce|create|generate|make} {larger|bigger}, persistent pore sizes than previously {possible|feasible|achievable|attainable|doable|probable}. 1218791-01-5 structure 791616-62-1 web PMID:24761411
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