Phenylthiosemicarbazones (PTSCs) are proton-coupled anion transporters with pH-switchable behaviour {known|recognized|identified} {to be|to become} regulated by an imine protonation equilibrium. Previously, chloride/nitrate exchange by PTSCs was {found|discovered|identified|located} {to be|to become} inactive at pH 7.{2|two} {due to|because of|as a result of|on account of|resulting from|as a consequence of} locking {of the|from the|in the|on the|with the|of your} thiourea anion binding {site|website|web site|internet site|web-site|web page} by an intramolecular hydrogen bond, and switched ON upon imine protonation at pH {4|four}.{5|five}. The rate-determining {process|procedure|method|approach|course of action} {of the|from the|in the|on the|with the|of your} pH switch, {however|nevertheless|nonetheless|even so|on the other hand|having said that}, was not examined. We {here|right here} {develop|create} {a new|a brand new} series of PTSCs and demonstrate their conformational behaviour by X-ray crystallographic {analysis|evaluation} and pH-switchable anion transport properties by liposomal assays. We report the surprising {finding|discovering|locating|obtaining|acquiring|getting} that the protonated PTSCs are {extremely|very|incredibly|really|particularly|exceptionally} selective for halides {over|more than} oxyanions in membrane transport. Owing {to the|towards the|for the} {high|higher} chloride {over|more than} nitrate selectivity, the pH-dependent chloride/nitrate exchange of PTSCs originates {from the|in the} rate-limiting nitrate transport {process|procedure|method|approach|course of action} {being|becoming|getting} inhibited at neutral pH. 120042-11-7 custom synthesis Buy183741-91-5 PMID:32695810
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