Synthetic random heteropolymers (RHPs) with {high|higher} chemical heterogeneity can self-assemble into single-chain nanoparticles that exhibit {features|attributes|functions|characteristics|capabilities|options} reminiscent of {natural|all-natural|organic} proteins, {such as|like|including|for example|for instance|which include} topological polymorphism. {Using|Utilizing|Making use of|Employing|Working with|Applying} all-atom molecular dynamics simulations, this {work|function|perform|operate} investigates the structure and single-chain mechanical unfolding of a library of four-component RHPs in water, studying the effects of sequence, composition, configuration, and molecular weight. {Results|Outcomes|Final results|Benefits} show that compactified RHPs can have {highly|extremely|very|hugely} dynamic unfolding behaviors {which are|that are} dominated by {complex|complicated} side-chain interactions and prove markedly {different|various|distinct|diverse|unique|distinctive} from their homopolymer counterparts. {For a|To get a|For any} {given|offered|provided} sequence and conformation, an RHP’s backbone topology can strongly {impact|influence|effect} its unfolding response, hinting {at the|in the} {importance|significance|value} of topological {design|style|design and style} {in the|within the|inside the} nanoscale mechanics of heteropolymers. {In addition|Additionally|Furthermore|Moreover|Also}, we {identify|determine|recognize} enthalpically-driven reconfiguration upon unfolding, observing a solvent-shielding protection mechanism {similar|comparable|equivalent|related} to protein stabilization by PEGylation. This {work|function|perform|operate} {provides|offers|gives|supplies|delivers} {the first|the very first|the initial} computational {evidence|proof} for the force-induced unfolding of protein-inspired multicomponent heteropolymers. 3-Methoxybenzensulfonyl chloride site 1334146-82-5 Price PMID:23771862
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