Transition metal-catalyzed allylic substitution reactions of pre-activated allylation agents with nucleophiles are extensively studied synthetic {methods|techniques|strategies|approaches|procedures|solutions} {that have|which have} enjoyed widespread applications in organic synthesis. The direct alkylation of allylic C–H bonds with nucleophiles, which minimizes pre-functionalization and converts {inexpensive|affordable|low-cost|economical|cheap}, abundantly {available|accessible|obtainable|offered|readily available|out there} {materials|supplies|components} to value-added alkenyl-substituted {products|goods|items|merchandise|solutions}, remains {challenging|difficult}. {Current|Present|Existing} {methods|techniques|strategies|approaches|procedures|solutions} {generally|usually|typically|normally|commonly|frequently} involve C–H activation, {require|need|demand|call for} {the use of|the usage of} noble-metal catalysts and stoichiometric chemical oxidants, and {often|frequently|usually|typically|generally|normally} show {limited|restricted} scope. {Here|Right here} we report an electrocatalytic allylic C–H alkylation reaction with carbon nucleophiles employing an {easily|effortlessly|very easily|simply|quickly|conveniently} {available|accessible|obtainable|offered|readily available|out there} cobalt-salen {complex|complicated} {as the|because the} molecular catalyst. These C(sp3)–H/C(sp3)–H cross-coupling reactions proceed {through|via|by means of|by way of} H2 evolution and {require|need|demand|call for} no external chemical oxidants. Importantly, the mild {conditions|circumstances|situations} and radical mechanism {ensure|make sure|make certain|guarantee|assure} {excellent|superb|outstanding|exceptional|great|fantastic} functional group tolerance and substrate compatibility with {both|each} linear and branched terminal alkenes. The synthetic utility {of the|from the|in the|on the|with the|of your} electrochemical {method|technique|approach|strategy|system|process} is highlighted by its scalability ({up to|as much as} 200 mmol scale) and its {successful|effective|productive|profitable|prosperous|thriving} application {in the|within the|inside the} late-stage functionalization of {complex|complicated} structures. 6-Chloro-5-methylpyridazin-3(2H)-one In stock 1,7-Dibromoheptane Chemscene PMID:25147652
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