A modular {approach|method|strategy} to prepare tri- and tetracyclic carbazoles by a sequential [3+2]heteroannulation is described. {First|Initial|Very first|1st|Initially}, op-timization of a Pd-catalyzed Buchwald-Hartwig amination followed by C/N-arylation {in a|inside a|within a} one-pot {process|procedure|method|approach|course of action} is established. Second, mechanistic analyses identified the origins of chemo- and regioselective sequential {control|manage|handle} of {both|each} bond-forming {steps|actions|measures|methods}. {Finally|Lastly|Ultimately}, the substrate scope is demonstrated by the preparation of a {range|variety} of tri- and tetracyclic carbazoles, {including|such as|which includes|like} expedient access to {several|a number of|numerous|many|various|quite a few} {natural|all-natural|organic} {products|goods|items|merchandise|solutions} and anti-cancer agents. 5-Bromo-2-(difluoromethyl)pyrimidine web 3-Hydroxy-5-methoxybenzaldehyde site PMID:23935843
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