{Methods|Techniques|Strategies|Approaches|Procedures|Solutions} for {rapid|fast|speedy} preparation of densely functionalized and stereochemically {complex|complicated} N-heterocyclic scaffolds are in demand for exploring {potential|possible|prospective} new bioactive chemical space. This {work|function|perform|operate} describes experimental and computational {studies|research} to {better|much better|far better|greater|superior|improved} {understand|comprehend|realize|recognize|fully grasp|have an understanding of} the {features|attributes|functions|characteristics|capabilities|options} of aziridinium ylides as intermediates for the synthesis of {highly|extremely|very|hugely} substituted dehydromorpholines. The {development|improvement} of this chemistry has enabled the extension of aziridinium ylide chemistry {to the|towards the|for the} concomitant formation of {both|each} a C–N {and a|along with a|as well as a|plus a|and also a|in addition to a} C–O bond {in a|inside a|within a} manner that preserves the stereochemical {information|info|details|data|facts|information and facts} embedded {in the|within the|inside the} substrate. The chemistry is tolerant of a wide {range of|selection of|array of} functionalities {that can be|that may be} employed for DNA-encoded library (DEL) synthesis to prepare diverse libraries of heterocycles with {potential|possible|prospective} bioactivity. {In addition|Additionally|Furthermore|Moreover|Also}, {we have|we’ve|we’ve got} uncovered {several|a number of|numerous|many|various|quite a few} {key|important|crucial|essential} insights that describe the {importance|significance|value} of steric effects, rotational barriers {around|about} the C–N bond {of the|from the|in the|on the|with the|of your} aziridinium ylide, and non-covalent interactions (NCIs) {on the|around the} ultimate reaction outcome. These {critical|crucial|vital|essential|important} insights will {assist|help} {in the|within the|inside the} {further|additional} {development|improvement} of this chemistry to {generate|produce|create} novel and {complex|complicated} N-heterocycles {that will|which will|that can|that may|that could|that should} {further|additional} expand {complex|complicated} amine chemical space. 935845-20-8 Chemical name Price of 2-Aminoacetamide PMID:23522542
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