Conjugation {techniques|methods|strategies|tactics|approaches|procedures} are central to improvingintracellular delivery of bioactive {small|little|tiny|modest|smaller|compact} molecules. {However|Nevertheless|Nonetheless|Even so|On the other hand|Having said that}, trackingand assessing the {overall|general|all round} biological outcome {of these|of those} constructsremains poorly understood. We addressed this {issue|problem|concern|situation|challenge} by havingdeveloped a focused library of heterobivalent constructs {based|primarily based} onRho kinase inhibitors to probe {various|numerous|different|a variety of|several|many} scenarios. By comparinginduction of a phenotype of interest vs. cell viability vs. cellular uptake,we demonstrate that such conjugates {indeed|certainly} {lead to|result in|bring about|cause} divergent cellularoutcomes. (3-Bromo-1-propyn-1-yl)cyclopropane Data Sheet Imino(methyl)(phenyl)-l6-sulfanone In stock PMID:23522542
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