Direct and diastereoselective synthesis of vicinal anti-sec,tert-diols has been {achieved|accomplished} by zinc-mediated α- hydroxyallylation of aldehydes with cyclopropanols. The reaction {features|attributes|functions|characteristics|capabilities|options} the action of zinc enolized homoenolate, formed {via|by way of|through|by means of} ring opening of zinc cyclopropoxide and enolization {of the|from the|in the|on the|with the|of your} resulting homoenolate, as γ-oxyallyl nucleophile toward the carbonyl electrophile, which stands in contrast {to the|towards the|for the} previously described enolate mode {of the|from the|in the|on the|with the|of your} {same|exact same|identical|very same|similar} species. A bicyclic chairlike transition state wherein the aldehyde substituent favorably occupies the psuedoaxial position is proposed to account for the anti selectivity. 6-Bromo-5-fluoronicotinaldehyde Data Sheet 3-Amino-4-pyridinecarboxaldehyde Order PMID:25269910
Headquartered in New Jersey, USA, ChemScence is a global leading manufacturer and supplier of building blocks and fine research chemicals. We now have branches in Sweden and India. Our mission is to pave the way for drug discovery by providing the most innovative chemicals with the highest-level quality for a reasonable price.
Our Catalog Products
We deliver an extensive portfolio of products, including Building Blocks,Catalysts&Ligands,Synthetic Reagents,Material Science and ADC Linkers&Protac,.ChemScene now have over 600000 Building Blocks & Intermediates in our catalog and more than 70000 of them are in stock.
For details, please refer to the ChemScene website:https://www.chemscene.com