Plant-derived {natural|all-natural|organic} bioactive molecules are of {great|fantastic|excellent|wonderful|good|terrific} therapeutic {potential|possible|prospective} but their application in nanomedicine has been so far scarcely studied. This {work|function|perform|operate} aimed at comparing two methodologies, i.e. adsorption and in situ incorporation, to prepare hybrid polyphenol/hydroxyapatite nanoparticles. Two flavonoids, baicalin and its aglycone derivative baicalein, and two phenolic acids derived from caffeic acid, rosmarinic and chlorogenic acids, {were|had been|have been} studied. Adsorption {of these|of those} polyphenols on pre-formed hydroxyapatite nanoparticles {did not|didn’t} modify particles size or shape and loading was {less|much less|significantly less} than {10|ten} % (w/w). In contrast, presence of polyphenols {during the|throughout the|through the} synthesis of nanoparticles {significantly|considerably|substantially|drastically} impacted, and {sometimes|occasionally|at times|often|from time to time|in some cases} {fully|totally|completely} inhibited, hydroxyapatite formation, but recovered particles could exhibit {higher|greater|larger} loadings. Antioxidant properties {of the|from the|in the|on the|with the|of your} polyphenols {were|had been|have been} preserved {after|following|right after|soon after|immediately after|just after} adsorption but not when incorporated in situ. These {results|outcomes|final results|benefits} {provide|offer|supply|give|present|deliver} fruitful clues for the valorization of {natural|all-natural|organic} bioactive molecules in nanomedicineApixaban Chemical name 143062-85-5 supplier PMID:24278086
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