{Effective|Efficient|Successful|Powerful|Productive|Helpful} inhibition of sperm motility {using|utilizing|making use of|employing|working with|applying} a spermicide {can be|may be|could be|might be|is often|is usually} a promising {approach|method|strategy} in {developing|creating|building|establishing} non-invasive male contraceptive agents. Copper is {known|recognized|identified} to havecontraceptive properties and has been {used|utilized|employed|utilised|applied|made use of} clinically for decades as intrauterine contraceptive devices (IUDs) for contraception in females. Beyond that, the spermicidal useof copper has not been explored {much|a lot|significantly|considerably|substantially|a great deal} {further|additional}, {even though|although|despite the fact that} its use could also subduethe {harmful|dangerous|damaging} effects {caused|brought on|triggered} by the hormonal contraceptive agents {on the|around the} {environment|atmosphere}.Herein, we study the size, concentration and time dependent in vitro inhibition ofbovine spermatozoa by copper microparticles. The effectivity in inhibiting the sperm motility is correlated {to the|towards the|for the} {amount|quantity} of Cu2+ ions released by the particles {during|throughout|in the course of|for the duration of|through} incubation. The copper particles {cause|trigger|result in|lead to|bring about} direct suppression of sperm cell motility uponincubation and thereby show {potential|possible|prospective} as sperm inhibiting, hormone {free|totally free|free of charge|cost-free|absolutely free|no cost} candidate formale contraception beyond condoms. 2-(Bromomethyl)-4-fluoro-1-nitrobenzene Chemscene 3-Hydroxy-4-methylbenzonitrile Formula PMID:24883330
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