Dual Brønsted/Lewis acid catalysis involving environmentally benign, readily accessible protic acid and iron promotes site-selective tert-butylation of electron-rich arenes {using|utilizing|making use of|employing|working with|applying} di-tert-butylperoxide. This transformation inspired the {development|improvement} of a synergistic Brønsted/Lewis acid catalyzed aromatic alkylation that fills a gap {in the|within the|inside the} Friedel–Crafts reaction literature by employing unactivated tertiary alcohols as alkylating agents, {leading|top|major} to new quaternary carbon centers. Corroborated by DFT calculations, the Lewis acid serves a {role|function|part} in enhancing the acidity {of the|from the|in the|on the|with the|of your} Brønsted acid. {The use of|The usage of} non-allylic, non-benzylic, and non-propargylic tertiary alcohols represents an underexplored {area|region|location} in Friedel–Crafts reactivity. 61302-99-6 uses 1411774-27-0 web PMID:22943596
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