Difluoroalkylation of tertiary amides and lactams by an iridium-catalyzed reductive Reformatsky reaction
The synthesis of medicinally relevant α-difluoroalkylated amines by an iridium-catalyzed reductive alkylation of tertiary amides and lactams with difluoro-Reformatsky reagents, is described. This report {features|attributes|functions|characteristics|capabilities|options} the introduction of {various|numerous|different|a variety…