The behavior of proteins is closely related to the protonation states of the residues. Therefore, prediction and measurement of pKa are essential to understand the basic functions of proteins. In…
Novel halogen ring-disubstituted propyl 2-cyano-3-phenyl-2-propenoates, RPhCH=C(CN)CO2C3H7 (where R is 2-fluoro-5-methyl, 3-iodo-4-methoxy, 5-iodo-2-methoxy, 3,5-dichloro, 3,4-difluoro, 3,5-difluoro, 2-chloro-4-fluoro, 2-chloro-6-fluoro, 3-chloro-2-fluoro, and 3-chloro-4-fluoro) were prepared and copolymerized with styrene. The propenoates were synthesized…
Application of data science and machine learning (ML) techniques in the domain of materials science has been increasing by leaps and bounds recently. With the help of ML, through input…
Herein we {perform|carry out|execute} a seven-step chemical synthesis of aDNA-encoded macrocycle library (DEML) on DNA. Inspired bypolyketide and mixed peptide-polyketide {natural|all-natural|organic} {products|goods|items|merchandise|solutions}, the librarywas {designed|developed|created|made} to incorporate {rich|wealthy} backbone diversity.…
The thionolactone 3,3-dimethyl-2,3-dihydro-5H-benzodioxepine-5-thione (DBT) is shown to homopolymerize and, for the first time, copolymerize with styrene and methacrylates, introducing degradable thioester backbone functionality. The rapid copolymerization with styrene was exploited…
While QM/MM studies of enzymatic reactions are widely used in computational chemistry, the results of such studies are subject to numerous sources of uncertainty, and the effect of different choices…
Excitonic energy transfer in light harvesting complexes, the primary process of photosynthesis, operates with near-unity efficiency. Experimental and theoretical studies suggest that quantum mechanical wave-like motion of excitons in the…
The energy and entropy, expressed in free energy, determine the behavior of a system. Therefore, infinite knowledge of these two quantities leads to precise prediction of the system’s trajectories. Here,…
In calculations based on density functional theory, the “HOMO-LUMO gap” (difference between the highest occupied and lowest unoccupied molecular orbital energies) is often used as a low-cost, ad hoc approximation…
It is a common practice in ab initio molecular dynamics (AIMD) simulations of water to use an elevated temperature to overcome the over-structuring and slow diffusion predicted by most current…